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KMID : 1035220200120020036
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Korean Journal of Neuromuscular Disorders
2020 Volume.12 No. 2 p.36 ~ p.38
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A Guillain-Barre Syndrome with Anti-GQ1b and Anti-GT1a Antibodies Positivity Manifesting with Acute Bulbar Palsy and Subsequent Delayed Ophthalmoplegia
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Yoon Seon-Min
Bae Jong-Seok
Yoon Byeol-A
Kim Jong-Kuk
Kim Ye-Rim
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Abstract
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In Guillain-Barre syndrome (GBS) and its variant, anti-GQ1b antibody has a pathogenic role for ophthalmoplegia. In addition, anti-GT1a antibody is related with lower cranial nerve involvement. This report describes a 60-year-old male patient with GBS manifesting with initially isolated dysphagia and subsequently developed ophthalmoplegia. Both immunoglobulin G type anti-GQ1b and anti-GT1a antibodies were detected in the patient’s serum. A mechanism regarding subsequent involvement of respective cranial nerves remains to be elucidated.
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KEYWORD
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Gangliosides, Bulbar palsy, Ophthalmoplegia
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